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  • Title: Oral and topical antibiotic prescriptions for children in general practice.
    Author: de Bont EG, van Loo IH, Dukers-Muijrers NH, Hoebe CJ, Bruggeman CA, Dinant GJ, Cals JW.
    Journal: Arch Dis Child; 2013 Mar; 98(3):228-31. PubMed ID: 23268371.
    Abstract:
    OBJECTIVE: Most primary care clinical guidelines recommend restrictive antibiotic use for childhood infections. We investigated antibiotic prescription rates over time for oral and topical antibiotics for children (≤12 years) in the period 2000-2010. DESIGN, SETTING AND PATIENTS: Longitudinal observational study among children (≤12 years) in a large Dutch general practice database in the period 2000-2010. MAIN OUTCOME MEASURES: Oral and topical antibiotic prescribing rates per year and independent factors influencing antibiotic prescriptions. RESULTS: We analysed 108 555 patient-years during 2000-2010. At least one chronic disease was recorded in 15.8% of patient-years, with asthma most commonly registered. In 14.8% of the patient-years at least one antibiotic was prescribed, while 26.3% of these received two or more prescriptions. Young age and chronic disease had a significant effect on antibiotic prescriptions. Prescriptions for oral and topical antibiotics increased 4.9% and 1.8%, respectively, during 2000-2005 (p<0.001). Prescription rates for oral antibiotics decreased 3.3% during 2006-2010 (p<0.001), while topical prescribing rates remained stable. CONCLUSIONS: One in six children received at least one oral antibiotic prescription per year during 2000-2010. While topical prescription rates steadily increased during 2005-2010 and remained stable during 2006-2010, prescription rates for oral antibiotics increased significantly during the period 2000-2005 and then significantly decreased during the period 2006-2010. As clinical guidelines remained the same over this period, the effects could be contributed to the initiation of the Dutch nationwide pneumococcal vaccination campaign in 2006.
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