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  • Title: Identification of the metabolites of trichlorocarbanilide in the rat.
    Author: Warren JT, Allen R, Carter DE.
    Journal: Drug Metab Dispos; 1978; 6(1):38-44. PubMed ID: 23272.
    Abstract:
    The metabolism and excretion of 14C-labeled 3,4,4'-trichlorodiphenylurea has been studied in the rat after oral and iv administration. More than 80% of the administered radioactivity was excreted in the feces and urine over 5 days. Five isolated metabolites were characterized by mass spectrometry and by comparative thin-layer chromatography with synthesized compounds. Metabolites found include 2'-hydroxy-, 3'-hydroxy-, 6-hydroxy-, 2',6-dihydroxy- and 3',6-dihydroxy-3,4,4'-trichlorodiphenylurea.
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