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  • Title: The semi-quantitative calprotectin rapid test--is it useful in inflammatory bowel disease?
    Author: Dranga M, Dumitrescu G, Badea M, Blaj A, Mihai C, Prelipcean CC.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2012; 116(3):761-5. PubMed ID: 23272524.
    Abstract:
    AIM: To assess the efficiency of the dosage of the semi-quantitative calprotectin rapid test in evaluating the activity of inflammatory bowel diseases. MATERIAL AND METHODS: The prospective study included 87 patients with BII (50 with ulcerative colitis, 37 with Crohn disease) hospitalized between January 2011 - May 2012. The diagnosis was confirmed by colonoscopy and histological examination. Fecal calprotectin was measured by means of a semi-quantitative rapid test. RESULTS: There were 50 patients with UC and 37 with BC. 96% of the UC patients were evaluated during the active disease. 21 of them had a severe episode of active disease, 16 had a moderate one, while 10 had a mild activity episode. The correlation between the calprotectin values and lesions localization was analyzed, without finding any statistical differences. The data have shown a very strong correlation between the severity of the active disease, assessed through the UCDAI (Mayo) score, and the calprotectin value. Patients with CD manifested a linear correlation between the severity of the active disease and the calprotectin value. CONCLUSIONS: The rapid test for assessing calprotectin could be a useful non-invasive marker in appreciating the severity of clinical and biological disease activity.
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