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  • Title: Excretion of phenytoin into semen of rabbits and man. Comparison with plasma levels.
    Author: Swanson BN, Leger RM, Gordon WP, Lynn RK, Gerber N.
    Journal: Drug Metab Dispos; 1978; 6(1):70-4. PubMed ID: 23276.
    Abstract:
    The concentration of phenytoin (diphenylhydantoin, DPH) was measured in plasma and semen of rabbits and man. In the rabbit, a single iv injection of DPH (4.64 mg) resulted in a concentration-time curve for DPH in semen parallel to the concentration-time curve for DPH in plasma (t1/2beta = 171 +/- 29 min). A semen/plasma drug concentration ratio of 0.20 was maintained for at least 8 hr, demonstrating that DPH concentrations in semen are directly proportional to DPH concentrations in plasma. In epileptic subjects maintained on oral DPH the mean drug concentration in semen was 2.31 microgram/ml while that in plasma was 13.8 microgram/ml. The mean semen-plasma DPH concentration ratio in man was 0.17; this closely approximates the observed ratio in rabbits.
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