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  • Title: Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.
    Author: Mita Y, Noguchi-Yachide T, Ishikawa M, Hashimoto Y.
    Journal: Bioorg Med Chem; 2013 Feb 01; 21(3):608-17. PubMed ID: 23276450.
    Abstract:
    Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.
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