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  • Title: In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy.
    Author: Schwalbe RS, Hoge CW, Morris JG, O'Hanlon PN, Crawford RA, Gilligan PH.
    Journal: Antimicrob Agents Chemother; 1990 Jan; 34(1):161-3. PubMed ID: 2327754.
    Abstract:
    We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.
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