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  • Title: Cobalamin neuropathy. Is S-adenosylhomocysteine toxicity a factor?
    Author: Vieira-Makings E, Metz J, Van der Westhuyzen J, Bottiglieri T, Chanarin I.
    Journal: Biochem J; 1990 Mar 15; 266(3):707-11. PubMed ID: 2327959.
    Abstract:
    Cobalamin neuropathy was produced in cape fruit bats (Rousettus aegyptiacus) by a cobalamin-free diet combined with intermittent exposure to nitrous oxide, which inactivates cobalamin. There were no significant differences in S-adenosylmethionine/S-adenosylhomocysteine ratios in the central nervous system of cobalamin-deficient and cobalamin-replete bats. Taken with other data there are no grounds of support for a hypothesis that cobalamin neuropathy is the result of impaired methylation, however produced.
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