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  • Title: Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides.
    Author: Pham CD, Hartmann R, Müller WE, de Voogd N, Lai D, Proksch P.
    Journal: J Nat Prod; 2013 Jan 25; 76(1):103-6. PubMed ID: 23282083.
    Abstract:
    Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.
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