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  • Title: Evidence for the role of spinal cord systems in Parkinson's disease-associated pain.
    Author: Sage JI, Kortis HI, Sommer W.
    Journal: Clin Neuropharmacol; 1990 Apr; 13(2):171-4. PubMed ID: 2328508.
    Abstract:
    A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.
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