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  • Title: Resting-state FMRI single subject cortical parcellation based on region growing.
    Author: Blumensath T, Behrens TE, Smith SM.
    Journal: Med Image Comput Comput Assist Interv; 2012; 15(Pt 2):188-95. PubMed ID: 23286048.
    Abstract:
    We propose a new method to parcellate the cerebral cortex based on spatial dependancy in the fluctuations observed with functional Magnetic Resonance Imaging (fMRI) during rest. Our surface-based approach uses a region growing method. In contrast to previous methods, locally stable seed points are identified on the cortical surface and these are grown into a (relatively large 1000 to 5000) number of spatially contiguous regions on both hemispheres. Spatially constrained hierarchical clustering is then used to further combine these regions in a hierarchical tree. Using short-TR resting state fMRI data, this approach allows a subject specific parcellation of the cortex into anatomically plausible subregions, identified with high scan-to-scan reproducibility and with borders that delineate clear changes in functional connectivity.
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