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  • Title: [Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas].
    Author: Cai F, Zhang YD, Dai CX, Liu XH, Yang YK, Yao Y, Wang RZ.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2012 Dec; 34(6):640-4. PubMed ID: 23286415.
    Abstract:
    Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
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