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  • Title: Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents.
    Author: Dai HL, Zheng JB, Lin M, Zheng J, Zhou FS, Dong XC, Guo L, Liu JW, Wen R.
    Journal: Yao Xue Xue Bao; 2012 Oct; 47(10):1347-57. PubMed ID: 23289148.
    Abstract:
    A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
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