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  • Title: Clinical experiences with Creutzfeldt-Jakob disease: three case studies.
    Author: Szucs A, Várallyay P, Osztie E, Papp E, Sólyom A, Finta L, Varga D, Barcs G, Holló A, Kamondi A.
    Journal: Ideggyogy Sz; 2012 Nov 30; 65(11-12):401-10. PubMed ID: 23289175.
    Abstract:
    The clinical picture, electroencephalographic, imaging and cerebrospinal fluid parameters as well as the molecular background of Creutzfeldt-Jakob disease have been well explored. The diagnostic criteria, offering clinicians a fair chance to identify these patients in vivo, have recently been updated. However, the diagnosis is still a challenge in everyday neurological routine. We report on three of our Creutzfeldt-Jakob patients for calling attention to the classical and the recently defined features of the disease. We conclude that based on the rapidly progressing neuropsychiatric syndrome Creutzfeldt-Jakob disease may be suspected; follow-up EEG may reveal the typical (pseudo)-periodic pattern with progressive deterioration of the background activity. In addition, diffusion-weighted brain MRI imaging (DWI) has high diagnostic value. Detection of 14-3-3 protein in the cerebrospinal fluid supports the in vivo diagnosis.
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