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  • Title: [Diffusion tensor imaging analyses of white matter in healthy siblings of schizophrenics].
    Author: Kang Z, Wei QL, Tang YX, Li LJ, Zheng LR, Guo XF, Zhang JB, Zhao JP.
    Journal: Zhonghua Yi Xue Za Zhi; 2012 Oct 23; 92(39):2772-4. PubMed ID: 23290166.
    Abstract:
    OBJECTIVE: To explore the diffusion tensor imaging (DTI) features of white matter in healthy siblings of schizophrenics. METHODS: Twenty healthy siblings of schizophrenics and 45 healthy controls without a family history of mental disorder. They responded to advertised recruitment during December 2009 and March 2012. All participants underwent diffusion weighted magnetic resonance images with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample t-test with SPM5 software. RESULTS: The healthy siblings of schizophrenics demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI: x = 9, y = 43, z = 4; cluster = 106). CONCLUSION: Reduced white matter integrity in right anterior cingulated may be a risk actor of schizophrenia.
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