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  • Title: [Thermosensitive TRP channels gene expression in hypothalamus of normal rats and rats adapted to cold].
    Author: Voronova IP, Tuzhikova AA, Kozyreva TV.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2012 Sep; 98(9):1101-10. PubMed ID: 23293814.
    Abstract:
    The gene expression of thermosensitive TRP (transient receptor potential) ion channels was studied by the method of quantitative reverse transcription-polymerase-chain-reaction (RT-PCR) in hypothalamus of control (normal) rats (5 weeks at the room temperature 20 +/- 22 degrees C) and rats adapted to cold (5 weeks at the room temperature 4 +/- 6 degrees C). For the first time in this brain region the expression of Trpv3 and Trpm8 genes was found, that was the evidence of the presence of TRPV3 and TRPM8 ion channels in the hypothalamus; it was made a comparison of the gene expression of the 6 thermosensitive ion channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8) and found that there was rather high expression of the genes of thermosensitive ion channels activated at temperatures above 30 degrees C, while, the gene expression level of cold sensitive TRPM8 and TRPA1 proved to be much lower; it was found that long-term cold adaptation modified the gene expression of TRPV3 ion channel. The findings support the assumption that thermosensitive TRP ion channels of hypothalamus may be involved in the mechanisms of thermal adaptation at the level of gene expression.
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