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  • Title: Direct electron transfer glucose biosensor based on glucose oxidase self-assembled on electrochemically reduced carboxyl graphene.
    Author: Liang B, Fang L, Yang G, Hu Y, Guo X, Ye X.
    Journal: Biosens Bioelectron; 2013 May 15; 43():131-6. PubMed ID: 23298623.
    Abstract:
    A glucose biosensor based on direct electron transfer of glucose oxidase (GOD) self-assembled on the surface of the electrochemically reduced carboxyl graphene (ERCGr) modified glassy carbon electrode has been reported. X-ray photoelectron spectroscopy (XPS) analyses of ERCGr indicate most of the oxygen-containing groups such as epoxy/ether groups and hydroxyl groups in the carboxyl graphene were eliminated, while carboxylic acid groups remained. GOD was immobilized on the ERCGr modified glassy carbon electrode via self-assembly. The cyclic voltammetric result of the electrode shows a pair of well-defined and quasi-reversible redox peaks with a formal potential of -0.467 V and a peak to peak separation of 49 mV, revealing that the direct electron transfer between GOD and the electrode has been achieved. The proposed biosensor exhibits a linear response to glucose concentrations ranging from 2 to 18 mM with a detection limit of 0.02 mM. Moreover, this facile, fast, environment-friendly and economical preparation strategy of ERCGr may be extended for the preparation of other graphene based enzyme electrode biosensors.
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