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  • Title: Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy.
    Author: Shy ME, Heiman-Patterson T, Parry GJ, Tahmoush A, Evans VA, Schick PK.
    Journal: Neurology; 1990 May; 40(5):842-4. PubMed ID: 2330115.
    Abstract:
    We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.
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