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  • Title: [C-peptide, diabetogenic factor and the blood anticoagulating system in patients with the insulin-dependent type of diabetes mellitus before and after heparin therapy].
    Author: Balabolkin MI, Kudriashov BA, Levitskaia ZI, Liapina LA, Ul'ianov AM.
    Journal: Probl Endokrinol (Mosk); 1990; 36(1):25-8. PubMed ID: 2330356.
    Abstract:
    The authors analyzed the results of investigation of insulin residual secretion determined by the concentration of C-peptide in response to the stimulation of 1 mg of glucagon. The blood level of the diabetogenic factor (DGF) and activity of the anticoagulative system (ACS) were studied in parallel in patients with insulin-dependent type of diabetes mellitus before and after heparin therapy. The blood DGF disappeared, ACS function was restored, and the patient's body resistance to blood hypercoagulation developed against a background of heparin therapy. A decrease in insulin residual secretion was shown to be related to a duration of diabetes mellitus.
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