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  • Title: [The dependence of estradiol and progesterone reception in the endometrium on its histological structure in women with the syndrome of luteal phase failure].
    Author: Savchenko ON, Arutiunian NA, Beskrovnaia NI, Levchenko RG, Khrustaleva GF.
    Journal: Probl Endokrinol (Mosk); 1990; 36(1):44-8. PubMed ID: 2330361.
    Abstract:
    A study of the level of the sex steroid receptors in the endometrium of women with the syndrome of insufficiency of the luteal phase of the cycle (ILP-syndrome) has shown that disorders of receptor processes affect, first of all, progesterone receptors. An increase in a degree of a delay of endometrial development was accompanied by a rise of the level of progesterone in the endometrium which depended on the estradiol-progesterone ratio in the circulation, detectable on the 20th day of the menstrual cycle. The ILP-syndrome is characterized by the sufficient induction of progesterone receptors at the end of the proliferative--the beginning of the luteal phase of the cycle and by their insufficient inhibition with a low level of progesterone in the middle of the luteal phase. Insufficient synthesis of receptors as a result of sharp hypoestrogenemia is less frequent. The primary affection of the receptor apparatus as a cause of the ILP-syndrome against a normal hormonal background in the examinees was undetectable.
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