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  • Title: [The cytological diagnostics of dysplasia and epidermoid carcinoma of the cervix in studying the nucleolar-organizing regions of chromosomes].
    Author: Bolgova LS, Tuganova TN, Alekseenko OI.
    Journal: Klin Lab Diagn; 2012 Nov; (11):36-41. PubMed ID: 23305016.
    Abstract:
    The study of the nucleolar-organizing regions of chromosomes in the cells of dys-plastically modified squamous epithelium and epidermoid cancer of cervix was carried out. The successive increase of quantita-tive content of main morphofunctional types of nucleoli is established including active compact and transient nucleolonemic-compact ones in accordance with in-crease of dysplastic modifications and appearance of signs of epidermoid cancer of cervix. The dominance of percentage content of large argyrophilic granules in nu-cleoli of nucleolonemic type under epidermoid cancer of cervix as compared with dysplasia is established. The algorithm of differentiating cytological diagnostics of the degree of dysplasia and epidermoid cancer of cervix is developed. This algo-rithm reflects the degree of structural functional modifications of nucleolar-organizing regions of chromosomes.
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