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  • Title: Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
    Author: Haneklaus M, O'Neill LA, Coll RC.
    Journal: Curr Opin Immunol; 2013 Feb; 25(1):40-5. PubMed ID: 23305783.
    Abstract:
    The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.
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