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  • Title: The reliability of frozen section diagnosis.
    Author: Torp SH, Skjørten FJ.
    Journal: Acta Chir Scand; 1990 Feb; 156(2):127-30. PubMed ID: 2330791.
    Abstract:
    We undertook a retrospective study of 594 consecutive diagnosis by frozen section. Clinically important discrepancies were found between the frozen section and final diagnoses in 18 (3%), and unimportant discrepancies in 35 (6%). The reasons for the discrepancies were misinterpretation in 22 (41%), the presence of focal lesions in 29 (55%), and technical errors in 2 (4%). There were 4 false positive and 18 false negative diagnoses, giving a sensitivity of 93% and a specificity of 99%. Diagnoses from frozen sections were deferred in 40 cases (7%). These results are in accordance with those of similar studies, and confirm that frozen section is a highly accurate, but not infallible, method of rapid histological diagnosis.
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