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  • Title: [Suppression by luteectomy of the simultaneous increase in intramammary pressure and blood oxytocin levels induced by the injection of PGF2-alpha in ewes].
    Author: Labussière J, Lacroix MC, Combaud JF, de la Chevalerie FA, Thomas P.
    Journal: Reprod Nutr Dev; 1990; 30(1):91-6. PubMed ID: 2331309.
    Abstract:
    Seven lactating Lacaune ewes underwent either a total luteectomy on day 19 of pregnancy (D19) (compensated from that stage by a daily progesterone supplementation of 25 mg to ensure embryonic survival; group 1:4 animals) or a control laparotomy (group 2: 3 animals). Intra-jugular injection of 200 micrograms of a synthetic PGF2 alpha analogue (Dinolytic, Upjohn) caused an increase in the intramammary pressure (IMP) and a concomitant rise in oxytocinaemia only in the presence of a corpus luteum, ie in all ewes of groups 1 and 2 before D19 and only in those of group 2 after that stage. These experiments confirm that the corpus luteum, and not the other ovarian compartments, releases oxytocin when prostaglandin F2 alpha is administered.
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