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  • Title: Colesevelam: a new and improved bile acid sequestrant?
    Author: Tziomalos K, Karagiannis A, Mikhailidis DP, Athyros VG.
    Journal: Curr Pharm Des; 2013; 19(17):3115-23. PubMed ID: 23317402.
    Abstract:
    Treatment with statins represents an essential component both of primary and secondary cardiovascular prevention strategies. However, a proportion of patients cannot reach low-density lipoprotein cholesterol (LDL-C) targets with the highest tolerable dose of a potent statin or is intolerant to statins. Several treatment options are available for these patients. Colesevelam is a relatively new bile acid sequestrant that decreases serum LDL-C levels. Moreover, colesevelam improves glycemic control and seems to be well-tolerated, at least in short-term studies. Therefore, colesevelam seems to be a useful tool for the management of high-risk patients who cannot achieve LDL-C targets with monotherapy with a potent statin.
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