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  • Title: Calcium uptake activity of cardiac sarcoplasmic reticulum in myo-inositol-treated diabetic rats.
    Author: Xiang H, McNeill JH.
    Journal: Gen Pharmacol; 1990; 21(2):251-4. PubMed ID: 2332144.
    Abstract:
    1. Cardiac function of STZ-diabetic rats has been shown to be partially improved by myo-inositol treatment. We studied the effect of myo-inositol on Ca2(+)-uptake activity in sarcoplasmic reticulum in diabetic animals. 2. Cardiac sarcoplasmic reticulum Ca2(+)-uptake activity was significantly depressed in 8-week diabetic rats. 3. Myo-inositol treatment could not improve Ca2(+)-uptake activity in diabetic rats. 4. The data suggest that the cardiac dysfunction in diabetic rats is due to factors other than the decreased Ca2(+)-uptake activity in sarcoplasmic reticulum.
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