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  • Title: Plasmapheresis with exchange as primary treatment for thrombotic thrombocytopenic purpura.
    Author: Dayoan ES, Dixon AC, Rizzo E, Nakamura JM.
    Journal: Hawaii Med J; 1990 Feb; 49(2):44, 46, 49-51. PubMed ID: 2332332.
    Abstract:
    Thrombotic thrombocytopenic purpura (TTP) is an uncommon disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever and renal and neurologic dysfunction. As a result of the availability of plasmapheresis, we can report the results of 5 patients treated with plasmapheresis and exchange transfusion who also received intravenous corticosteroids as adjunctive therapy. Our 5 patients had a mean age of 41 years, and presented with a mean platelet count of 39 x 10(9)/L. Four of the 5 patients responded to treatment and were discharged in excellent condition. The 5th patient succumbed to her disease. We concluded that plasmapheresis with exchange transfusion is a rapid and effective therapy for TTP.
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