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  • Title: Presumptive progressive multifocal leukoencephalopathy in multiple sclerosis after natalizumab therapy.
    Author: Eisele P, Szabo K, Hornberger E, Griebe M, Hennerici MG, Kieseier BC, Gass A.
    Journal: J Neuroimaging; 2014; 24(4):425-8. PubMed ID: 23323645.
    Abstract:
    BACKGROUND AND PURPOSE: To describe a patient with relapsing remitting MS who was treated with natalizumab for 36 months. First symptoms of presumptive progressive multifocal leukoencephalopathy (PML) appeared 14 weeks after her last natalizumab infusion. METHODS: Neurological examination, MRI and CSF analysis were performed. RESULTS: The lack of anti-inflammatory treatment response, clinical course, and serial MRI examinations showed lesion development typical for PML on diffusion-weighted and FLAIR MRI. CSF analysis for JC virus was tested negative twice. CONCLUSIONS: This case represents a presumptive PML after discontinuation of natalizumab treatment-similar to the definition established for PML in HIV patients.
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