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  • Title: Meta-analysis of MMP9-562C/T and the risk of coronary heart disease.
    Author: Li J, Lu H, Tao F, Zhou H, Feng G, He L, Zhou L.
    Journal: Cardiology; 2013; 124(1):53-9. PubMed ID: 23328249.
    Abstract:
    INTRODUCTION: Previous case-control studies have suggested that the -1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene (MMP9) are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis. METHODS: Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. RESULTS: The meta-analysis of the -1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The -1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08-1.45, p = 0.004). There was heterogeneity among the 12 studies (I2 = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16). CONCLUSIONS: The synthesis of available evidence supports the fact that the MMP9 -1562C/T polymorphism is a risk factor for CHD.
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