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  • Title: Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum.
    Author: Albayrak M, Karatas A, Demiraran Y, Erman H, Topuz S, Bıyık İ, Uzun H, Erkan M.
    Journal: J Matern Fetal Neonatal Med; 2013 Jun; 26(9):866-70. PubMed ID: 23330872.
    Abstract:
    OBJECTIVE: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). METHODS: Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. RESULTS: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p ≤ 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p ≤ 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. CONCLUSION: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.
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