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  • Title: An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst.
    Author: Chen Q, Liang J, Wang S, Wang D, Wang R.
    Journal: Chem Commun (Camb); 2013 Feb 25; 49(16):1657-9. PubMed ID: 23334197.
    Abstract:
    The first organocatalytic Michael-cyclization cascade reaction between isothiocyanato oxindoles and unsaturated pyrazolones has been developed. The multicyclic spiro[oxindole/thiobutyrolactam/pyrazolone] core structures containing three contiguous stereogenic centers, including two spiro quaternary centers, were prepared with excellent diastereo- (up to >20 : 1) and enantioselectivities (up to 99% ee).
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