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Title: Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells. Author: Liu BC, Lu XY, Song X, Lei KY, Alli AA, Bao HF, Eaton DC, Ma HP. Journal: Front Physiol; 2012; 3():483. PubMed ID: 23335899. Abstract: Scanning ion-conductance microscope (SICM), which enables high-resolution imaging of cell surface topography, has been developed for over two decades. However, only recently, a unique scanning mode is increasingly used in biological studies to allow SICM to detect the surface of live cells. More recently, in combination with confocal microscopy and patch-clamp electrophysiological techniques, SICM allows investigators to localize proteins or ion channels in a specific nanostructure at the cell surface. This article will briefly review SICM nanotechnique and summarize the role of SICM in biological studies.[Abstract] [Full Text] [Related] [New Search]