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  • Title: Synthesis of aminosterols and their derivatives.
    Author: Shafiullah, Singh RK, Jamaluddin M, Ogura H, Takayanagi H.
    Journal: Steroids; 1990 Mar; 55(3):120-2. PubMed ID: 2333658.
    Abstract:
    Reactions of steroidal epoxides such as 5,6 alpha-epoxy-5 alpha-cholestane (I) and its 3 beta-chloro (II) and 3 beta-acetoxy (III) analogs with urea in dimethylformamide afforded 6 beta-amino-5 alpha-cholestan-5-ol (IV-VI), 6 beta-amino-N-formyl-5 alpha-cholestan-5-ol (VII-IX), and 6 beta-amino-N-amido-5 alpha-cholestan-5-ol (X-XII), along with the 5 alpha-cholestane-5,6 beta-diol (XIII-XV). In addition to these compounds, the 3 beta-acetoxy analog also afforded the N-carboxyl derivative (XVI).
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