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  • Title: Selection and characterization of colorectal cancer cell-specific peptides.
    Author: Wang H, Ma C, Li R, Guo Y, He Y, Wang X, Chen Y, Hou Y.
    Journal: Biotechnol Lett; 2013 May; 35(5):671-7. PubMed ID: 23338703.
    Abstract:
    To develop a novel peptide probe for imaging detection of colorectal cancer, a 12-mer phage display library was used to select peptides that bind specifically to the human colorectal cancer cell line Caco-2. After four rounds of panning, four phage clones that bound specifically to the Caco-2 cells were selected. The phage clone SP-2 had a particularly high affinity and specificity for Caco-2 cells. This clone was identified using a series of methods. The peptide SP-2 that was displayed on phage SP-2 exhibited a high specificity to Caco-2 cells. Thus, the peptide SP-2 could be a candidate probe for the detection of colorectal cancer.
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