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  • Title: [Early and late effects of the cytogenetic action of doxorubicin].
    Author: Klimova MIu, Novitskiĭ VV, Gol'dberg ED.
    Journal: Antibiot Khimioter; 1990 Jan; 35(1):30-2. PubMed ID: 2334242.
    Abstract:
    Cytogenetic disorders in hemopoietic cells of the bone marrow were studied on mice CBA at early and late periods after exposure to MIDs of doxorubicin, an anthracycline antibiotic. It was shown that at the early period doxorubicin induced aberrations, mainly of the chromatid type, in the hemopoietic cells of the bone marrow. Instability of the genetic apparatus of the hemopoietic cells observed for 3 months of the experiment was likely to be the immediate cause of the disorders in hemopoiesis at the late periods after exposure to doxorubicin.
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