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  • Title: Hyperopia in complicated Leber's congenital amaurosis.
    Author: Dagi LR, Leys MJ, Hansen RM, Fulton AB.
    Journal: Arch Ophthalmol; 1990 May; 108(5):709-12. PubMed ID: 2334331.
    Abstract:
    We studied the refractive status of 13 children with Leber's congenital amaurosis. Seven had the disease complicated by neurological or other systemic abnormalities, while the other 6 patients had only ophthalmic abnormalities. All 13 patients were hyperopic. The magnitude of hyperopia did not differ significantly between the complicated and uncomplicated groups. Therefore, one cannot, as previously suggested, use the presence of high hyperopia to differentiate an uncomplicated form of Leber's congenital amaurosis from one complicated by neurologic or other systemic abnormalities. The concurrence of hyperopia with Leber's congenital amaurosis should not steer the physician away from careful neurologic systemic or biochemical evaluation of the child.
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