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  • Title: Role of protein synthesis in the accumulation of ferritin mRNA during exposure of cells to iron.
    Author: Mattia E, den Blaauwen J, van Renswoude J.
    Journal: Biochem J; 1990 Apr 15; 267(2):553-5. PubMed ID: 2334409.
    Abstract:
    The iron-induced biosynthesis of ferritin is regulated at the translational level via multiple mechanism. A prolonged exposure of cells to iron leads to a marked increase in ferritin mRNA levels caused by stabilization of the message. Here we show that this stabilization requires the synthesis de novo of an iron-inducible protein factor.
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