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  • Title: [Role of the cellular Na+/H+ exchange and glycolysis inhibition by the antiviral action].
    Author: Kirillov VA, Goreva LN, Votiakov VI.
    Journal: Biull Eksp Biol Med; 1990 Jan; 109(1):33-5. PubMed ID: 2334793.
    Abstract:
    Remantadine has been shown to induce a decrease in acidification rate of incubation medium by chick embryo fibroblasts, caused both by Na+/H+ exchange and diffusion of lactic acid, the final product of glycolysis. The degree of acidification rate decrease grew with increasing concentration and time of cell incubation with preparation. Possible implementation of the inhibitory effect of remantadine on acid-dependent process of influenza virus uncoating by decreasing cellular Na+/H+ exchange and glycolysis is discussed.
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