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  • Title: Study of alpha-thalassemia in northeastern Thailand at the DNA level.
    Author: Hundrieser J, Laig M, Yongvanit P, Sriboonlue P, Sanguansermsri T, Kühnau W, Pape M, Flatz G.
    Journal: Hum Hered; 1990; 40(2):85-8. PubMed ID: 2335370.
    Abstract:
    The frequency of alpha-thalassemias in a general population sample from northeastern Thailand and in an Austroasiatic group with high frequencies of hemoglobin E and beta-thalassemia, the So, was estimated using DNA techniques. Among 64 healthy adult subjects from the Khonkaen and Ubol areas, the following haplotype frequencies were determined: alpha alpha, 0.742; -alpha 3.7 (subtype I), 0.148; -alpha 4.2, 0.016; -alpha del, 0.008; alpha Constant Spring alpha, 0.055; --SEA, 0.023, and alpha alpha alpha (triplicated alpha-globin gene), 0.008. In the So group, the combined frequency of alpha-thalassemia chromosomes was 0.525.
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