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  • Title: Asymmetric rearrangement of racemic epoxides catalyzed by chiral Brønsted acids.
    Author: Zhuang M, Du H.
    Journal: Org Biomol Chem; 2013 Mar 07; 11(9):1460-2. PubMed ID: 23361172.
    Abstract:
    This paper describes a chiral Brønsted acid catalyzed asymmetric 1,2-rearrangement of racemic epoxides via a hydrogen-shift process for the synthesis of chiral aldehydes, and, followed by a reduction, a variety of optically active alcohols can be furnished in moderate yields with up to 50% ee. Especially, a facile one-pot synthesis of chiral alcohols directly from simple alkenes by a sequential epoxidation, rearrangement, and reduction has also been realized.
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