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  • Title: Delayed diagnosis of cryptococcal meningoencephalitis due to negative cryptococcal antigen test.
    Author: Kessler B, Bally F, Hewer E, Sendi P.
    Journal: BMJ Case Rep; 2013 Jan 29; 2013():. PubMed ID: 23365165.
    Abstract:
    Cryptococcus spp. commonly causes infection in immunocompromised hosts. Clinical presentation of cryptococcal meningoencephalitis (CM) is variable, but headache, fever and a high intracranial pressure should suggest the diagnosis. The cryptococcal antigen test is a specific and sensitive rapid test that can be performed on blood or cerebrospinal fluid. We report a case of CM in a patient with previously undetected lymphocytopenia. Because cryptococcal antigen test results were negative, diagnosis and treatment were delayed.
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