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  • Title: Reliability of the 30-minute ACTH test in assessing hypothalamic-pituitary-adrenal function.
    Author: Lindholm J, Kehlet H, Blichert-Toft M, Dinesen B, Riishede J.
    Journal: J Clin Endocrinol Metab; 1978 Aug; 47(2):272-4. PubMed ID: 233665.
    Abstract:
    An insulin hypoglycemia test and a 30-min ACTH test were performed in 90 patients with proved or suspected hypothalamic-pituitary-adrenal hypofunction and in 10 normal subjects. The peak plasma cortisol concentration during hypoglycemia and the cortisol concentration at 30 min after injection of 250 micrograms corticotropin 1-24 were compared. A very close correlation (r = 0.92) was found between the the two concentrations, with no major discrepancy in any case. It is concluded that the short ACTH test accurately reflects the integrated hypothalamic-pituitary-adrenal function, as assessed by the insulin hypoglycemia test.
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