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  • Title: [The effect of starvation during an early postnatal period on carbohydrate metabolism in the swine brain].
    Author: Snityns'kyĭ VV.
    Journal: Ukr Biokhim Zh (1978); 1990; 62(1):55-9. PubMed ID: 2336725.
    Abstract:
    Metabolism of carbohydrates in the brain of 110-day-feti, newborns (before taking the colostrum), 1-day-old and 5-day-old piglets, grown under sows or starved for 24 hours has been studied. Examination of brain slices with the use of 1-14C glucose and 6-14C glucose and determination of the glycolysis-limiting enzymes activity have shown that glycolysis is the main pathway of glucose utilization in the central nervous system of pigs during the transition from prenatal to postnatal development. The major portion of NADPH in the brain of new born piglets is supplied by dehydrogenases of the pentose-phosphate pathway. The increased activities of NADP-dependent malate and citrate dehydrogenases are found in the cytoplasm of astrocytes during the neonatal period. The decreased intensity of glycolysis and pentose-phosphate pathway in the brain of 1-day-old piglets is associated with the increased rate of malate and isocitrate oxidation. Starvation for 24 hours causes changes in the carbohydrate metabolism rates in the brain of piglets. The pentose-phosphate pathway rate increases by 70-80 per cent in the brain structures of piglets of the both groups. Besides, the iso-CDG activity also rises in the brain of 5-day-old animals. The high level of oxidation-reduction processes in the brain of older piglets at active glycolysis is supposed to be one of the peculiarities of energy metabolism in the central nervous system of animals which are resistant to starvation.
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