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  • Title: (S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones.
    Author: Westphal R, Waltzer S, Mackfeld U, Widmann M, Pleiss J, Beigi M, Müller M, Rother D, Pohl M.
    Journal: Chem Commun (Camb); 2013 Mar 11; 49(20):2061-3. PubMed ID: 23370615.
    Abstract:
    We report the first rationally designed (S)-selective MenD from E. coli for the synthesis of functionalized α-hydroxy ketones. By mutation of two amino acids in the active site stereoselectivity of the (R)-selective EcMenD (ee > 93%) was inverted giving access to (S)-5-hydroxy-4-oxo-5-phenylpentanoate derivatives with stereoselectivities up to 97% ee.
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