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  • Title: [Dangerous side effects of lithium therapy].
    Author: Ehle G, Uebelhack R.
    Journal: Psychiatr Neurol Med Psychol Beih; 1977; 22-23():177-82. PubMed ID: 233713.
    Abstract:
    A report is made on two cases of a pharmacogenic delirium as a result of combined lithium-haloperidol therapy, and on one case of lithium-induced diabetes insipidus renales with second-degree high pressure. Also, the development of a hydrocephalus internus male-resorptivus through lithium is discussed. In all patients there was a possible disposition due to old age or cerebral injury. Based on their effect on synaptic transmission the potentiating effect of lithium and haloperidol is discussed. Under the influence of Na-K stimulated ATPase and, thus, of active transport and adenylcyclase a basic mechanism of lithium therapy and its side-effects is seen.
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