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  • Title: [DNA synthesis in the foam cells of the vascular wall in experimental atherosclerosis in rabbits].
    Author: Babushkina TG, Bobryshev IuV, Vinogradov AG.
    Journal: Arkh Patol; 1990; 52(1):47-53. PubMed ID: 2337393.
    Abstract:
    Proliferative activity of the aortic intima cells in the course of experimental rabbit hypercholesterolemia is studied. The most intensive DNA synthesis was found in macrophages and smooth cells transforming into the foam cells as shown by electron-microscopic radioautographic analysis. DNA synthesis by damaged and dying foam cells is shown. Cytophotometric analysis showed the small proportion of foam cells in the atherosclerotic lesions to be polyploid.
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