These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Replication of European rheumatoid arthritis loci in a Pakistani population.
    Author: Jalil SF, Bhatti A, Demirci FY, Wang X, Ahmed I, Ahmed M, Barmada MM, Malik JM, John P, Kamboh MI.
    Journal: J Rheumatol; 2013 Apr; 40(4):401-7. PubMed ID: 23378462.
    Abstract:
    OBJECTIVE: Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. METHODS: We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. RESULTS: Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. CONCLUSION: Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.
    [Abstract] [Full Text] [Related] [New Search]