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  • Title: Difference in renal alpha-galactosidase levels in male and female Chinese hamsters (Cricetulus griseus).
    Author: Chang AY.
    Journal: Comp Biochem Physiol B; 1978; 61(1):133-7. PubMed ID: 233797.
    Abstract:
    1. The activity of alpha-galactosidase was found to be significantly higher in the kidney of female than that of male Chinese hamsters in a highly inbred colony but its activity in liver, heart and spleen remained similar between female and male animals. 2. Partially purified renal alpha-galactosidase by sequential column chromatography on Sepharose 6B and DEAE-Sepharose CL-6B showed identical elution profiles, pH optima (4.5), KmS (4.4 mM) and heat-inactivation curves between enzymes of male and female animals. 3. Thus, the observed higher activity of renal alpha-galactosidase in the females was due to elevated enzyme concentration, not a result of enzyme polymorphism.
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