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  • Title: Quinolinesulfonamides of aryloxy-/arylthio-ethyl piperidines: influence of an arylether fragment on 5-HT1A/5-HT7 receptor selectivity.
    Author: Grychowska K, Marciniec K, Canale V, Szymiec M, Glanowski G, Satała G, Maślankiewicz A, Pawłowski M, Bojarski AJ, Zajdel P.
    Journal: Arch Pharm (Weinheim); 2013 Mar; 346(3):180-8. PubMed ID: 23381952.
    Abstract:
    The solid-phase synthesis of a new series of 19 biomimetics of long-chain arylpiperazines, namely flexible quinoline sulfonamides of aryl(heteroaryl)oxy-/heteroarylthio-ethyl 4-aminomethylpiperidines, is reported. Various structural modifications applied followed by biological evaluation for 5-HT1A, 5-HT6, and 5-HT7 receptors gave further support of a possible replacement of arylpiperazine with aryloxy-/arylthio-ethyl derivatives of alicyclic amines and control of receptor selectivity upon diversification in the aryl(heteroaryl)oxy-/heteroarylthio-ethyl fragment.
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