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  • Title: Sulphamethoxazole acetylation in fast and slow acetylators.
    Author: Bozkurt A, Basci NE, Isimer A, Tuncer M, Erdal R, Kayaalp SO.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1990 Apr; 28(4):164-6. PubMed ID: 2338369.
    Abstract:
    Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
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