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  • Title: Pharmacokinetics of imipenem/cilastatin in neutropenic patients with haematological malignancies.
    Author: Janmohamed RM, Leyland MJ, Kelly J, Farrell I.
    Journal: J Antimicrob Chemother; 1990 Mar; 25(3):407-12. PubMed ID: 2338419.
    Abstract:
    The pharmacokinetics of imipenem/cilastatin were studied in febrile neutropenic patients with haematological malignancies. The peak plasma concentrations (36.4 +/- 4.96 mg/l), plasma half-life (60 min), volume of distribution (0.28 +/- 0.02 l/kg) and plasma clearance (3.23 +/- 0.38 ml/min/kg) were comparable with those in normal healthy volunteers suggesting that the drug handling is not appreciably altered in this group of patients. The administration of 12.5 mg/kg (max 1 g), 6-hourly achieved levels that were up to 3.5 times MICs of most relevant bacteria. The drug therefore has a potential use as empirical monotherapy in febrile neutropenic patients.
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